New Insights into Malaria’s Liver Stage Unveiled by Spatial Transcriptomics
Source-technologynetworks.com A pioneering study published in Nature Communications has provided new insights into the liver stage of malaria parasite, which is a critical yet poorly understood phase of its lifecycle. Researchers from Stockholm University, in collaboration with international experts, have utilized Spatial Transcriptomics and single-cell RNA-sequencing to create an unprecedented spatio-temporal map of malaria infection within the mouse liver. This innovative approach allows for the visualization of gene expression across liver tissues, shedding light on how malaria parasites interact with their host during this crucial stage. Technological Advances in Malaria Research The study, led by Johan Ankarklev from Stockholm University’s Department of Molecular Biosciences, was conducted in partnership with research groups from the Royal Institute of Technology, Karolinska Institute, National Institutes of Health, and VIB. The combination of Spatial Transcripto...