Heparan-Sulfate Proteoglycans Influence Alzheimer’s Disease Cell Pathology
Source-Alzheimers-News-Today Alzheimer’s disease pathology remains a challenging condition marked by amyloid plaques, neurofibrillary tangles, and lipid accumulation in glial cells. While treatments targeting these features have shown some success, other cellular deficits, especially in early-onset familial forms, persist. Genetic studies have highlighted mutations in genes related to membrane trafficking, immunity, and cholesterol metabolism as risk factors. Alzheimer’s Disease Pathology: Insights from Recent Research Recently published in IScience, a study examined heparan-sulfate-modified proteoglycans (HSPGs) and their impact on Alzheimer’s disease pathology. Researchers utilized mouse astrocytes and human cell cultures to investigate how HSPGs influence autophagy, mitochondrial function, and lipid synthesis. They also explored whether altering HSPG signaling could mitigate the effects of mutated presenilin (PSEN1) in Drosophila models. HSPGs are crucial in ...